ABSTRACT
Objective@#To explore the viral pathogens in hospitalized children with acute respiratory tract infection in Weifang.@*Methods@#Nasopharyngeal secretion (NPS) samples were collected from hospitalized patients with acute respiratory tract infection from July 2016 to June 2017. The NPS samples were detected for 16 respiratory virus types/subtypes including influenza A virus (FluA), influenza B virus (FluB), seasonal influenza A HlNl virus (sH1N1), parainfluenza virus types 1, 2 and 3 (PIV-1, 2, 3), respiratory syncytial virus A (RSVA), respiratory syncytial virus B (RSVB), human rhinovirus (HRV), adenovirus (ADV), human metapneumovirus (HMPV), four coronavirus sybtypes (Cov-NL63, 229E, OC43, HKUl) and human bocavirus (BoV) by multiplex reverse transcription polymerase chain reaction (RT-PCR) assays based on automatic capillary electrophoresis.@*Results@#A total of 769 children with respiratory tract infection were enrolled, and the overall positive rate for the 16 common respiratory tract viruses was 33.68% (259/769). The positive rates were as follows: RSV (9.23%), PIV (7.93%), Flu (6.89%), HRV (4.68%), ADV (3.38%), HMPV (1.69%), CoV (0.91%), BoV (0.65%). The positive rate of viral detection showed significant differences among different age groups (χ2=8.724, P=0.033), and the highest positive rate was noted in the age group of 6 months to 1 year. The overall positive rate of viral detection showed a significant difference in terms of seasonal distribution, with a peak prevalence in winter.@*Conclusions@#RSV was the main respiratory tract virus among children in Weifang, especially in winter and spring. The distribution of viruses in children with respiratory tract infection was associated with age and season.
ABSTRACT
Rhinovirus(RV) infection can lead to asymptomatic,mild symptoms from the upper respiratory tract to severe symptoms from the lower respiratory tract.RV is dentified as an important contributor to wheezing illness in preschool children.Wheezing is a symptom of airway obstruction,and preschool children wheezing with RV is associated with the development of asthma at school age.There is a debate whether there is difference in response to RV infection or if wheezing with RV only reveals a preexisting impairment that promotes asthma mainly in predisposed children.The development of molecular diagnostics to detect respiratory viruses has provided new insights into the role of RV infections.The review aims to discuss the relationship between RV infection and asthma.